Relinquish-M Tablet (Artemisinin 62.50mg + Piperaquine 375mg)

What Is Relinquish-M Tablet?

Relinquish-M Tablet is a combination medication used in the treatment of malaria, specifically caused by Plasmodium falciparum and Plasmodium vivax, the two most common malaria-causing parasites. The tablet contains two active ingredients: Artemisinin (62.5 mg) and Piperaquine (375 mg). Both of these compounds work together to target and kill the malaria parasite, reducing the severity of symptoms and preventing further complications.

• Artemisinin is derived from the herb Artemisia annua and is known for its potent antimalarial activity. It acts rapidly to eliminate parasites from the bloodstream.
• Piperaquine, on the other hand, is a long-acting antimalarial that works by inhibiting the growth of the parasite and preventing it from developing resistance.

This combination is effective in clearing the infection more quickly and reducing the chances of relapse, making it an important treatment for uncomplicated malaria.

How Does Relinquish-M Tablet Work?

The Artemisinin and Piperaquine combination in Relinquish-M Tablet works in two complementary ways to fight malaria:

1. Artemisinin:
   Artemisinin acts on the Plasmodium parasites by binding to iron in their heme group and forming a highly reactive oxygen molecule, which kills the parasite. This rapid action eliminates the parasites in the bloodstream, reducing fever and other malaria-related symptoms.
2. Piperaquine:
   Piperaquine, a quinoline derivative, works by disrupting the parasitic cell’s metabolism. It inhibits the parasite’s ability to replicate and survive in the bloodstream. Piperaquine has a longer half-life than Artemisinin, which helps to prevent relapse by ensuring the drug remains active in the body for an extended period.

Together, Artemisinin and Piperaquine offer a dual approach to combat malaria, targeting the parasite at different stages of its lifecycle. Artemisinin provides rapid relief, while Piperaquine ensures longer-lasting efficacy.

Benefits of Relinquish-M Tablet

1. Effective Treatment for Malaria:
   The combination of Artemisinin and Piperaquine is highly effective against Plasmodium falciparum and Plasmodium vivax. It works faster than many other antimalarial drugs, providing relief from malaria symptoms such as fever, chills, and fatigue.
2. Prevents Relapse:
   The long-acting properties of Piperaquine reduce the risk of malaria relapsing after treatment. It helps in preventing the resurgence of the parasite, especially in individuals with Plasmodium vivax malaria, where relapse is common due to dormant liver stages.
3. Dual Action:
   By combining a fast-acting Artemisinin derivative with a longer-lasting antimalarial like Piperaquine, Relinquish-M Tablet provides a broad spectrum of action, targeting both the acute phase and the relapse phase of malaria.
4. Reduced Risk of Resistance:
   The combination therapy lowers the risk of the parasite developing resistance, a significant concern with single-drug treatments. By using two different mechanisms, the likelihood of the malaria parasite surviving and becoming resistant is minimized.
5. Well-Tolerated:
   Relinquish-M is generally well-tolerated by patients, especially when taken as prescribed. It is a safer alternative compared to other antimalarial therapies, especially in areas where resistance to other drugs is a concern.

How to Take Relinquish-M Tablet

The correct dosage and usage of Relinquish-M Tablet are crucial for ensuring effectiveness and minimizing side effects. Here’s how it should be taken:

1. Dosage:
   • For uncomplicated malaria, the typical dose is one tablet of Relinquish-M (62.5 mg Artemisinin + 375 mg Piperaquine), twice a day for 3 days.
   • The tablet should be taken with food to improve absorption and reduce the risk of stomach upset.
   • In cases of severe malaria or if prescribed differently by your healthcare provider, the dosage may vary.
2. Timing:
   • It’s essential to follow the prescribed schedule without missing doses. Taking the medication on time ensures that the drug remains effective throughout the treatment period.
3. Missed Dose:
   • If you miss a dose, take it as soon as you remember, unless it’s almost time for the next dose. Do not take two doses at the same time to make up for a missed one.
4. Complete the Treatment:
   • Even if you start feeling better before completing the treatment, it’s important to finish the entire course to prevent relapse and ensure the complete eradication of the malaria parasite.

Who Makes Relinquish-M Tablet?

Relinquish-M Tablet is manufactured by Zydus Cadila, a well-known pharmaceutical company that specializes in the development and production of generic drugs. Zydus Cadila is committed to providing affordable and effective medications, especially for malaria, a major health concern in many developing countries.

Is Relinquish-M Tablet Safe for Humans?

Yes, Relinquish-M Tablet is considered safe for humans when taken as prescribed by a healthcare provider. It has undergone rigorous clinical testing for efficacy and safety and has been approved for use in the treatment of malaria. However, like any medication, it is important to follow dosing instructions carefully and consult your doctor if you have underlying conditions.

1. Pregnancy and Breastfeeding:
   Relinquish-M should be used during pregnancy only if the benefits outweigh the risks, and it should be avoided in the first trimester. Women who are breastfeeding should also consult their healthcare provider before using this medication.
2. Liver or Kidney Disease:
   Individuals with severe liver or kidney disease should use this medication with caution. Your doctor may adjust the dosage or suggest alternative treatments.
3. Drug Interactions:
   Inform your healthcare provider of any other medications you are taking, especially those used for cardiac conditions or antifungal treatments, as they may interact with the ingredients in Relinquish-M.

Side Effects of Relinquish-M Tablet

While Relinquish-M is generally well-tolerated, it can cause some side effects in certain individuals. Common side effects include:

• Headache
• Nausea
• Dizziness
• Abdominal pain
• Fatigue
• Diarrhea

In rare cases, more serious side effects may occur, such as:

• Allergic reactions, including rash, swelling, or difficulty breathing
• Liver problems, such as yellowing of the skin or eyes
• Heart issues, including abnormal heart rhythms

If you experience any severe or unusual symptoms, seek immediate medical attention.

Disclaimer

The information provided here is for educational purposes only and should not be used as a substitute for medical advice. Always consult with a qualified healthcare provider before starting any medication, including Relinquish-M Tablet. Your doctor will evaluate your specific condition and provide personalized recommendations based on your health history and needs.